2019

 
untitled.png
 

47. Jess, K.; Kitagawa, K.; Tagawa, T. K. S.; and Blum, S. A. “Microscopy Reveals: Impact of Lithium Salts on Elementary Steps Predicts Organozinc Reagent Synthesis and Structure” J. Am. Chem. Soc. 2019, ASAP Link

Picture1.png

46. Easter, Q. T.; Garcia IV, A.; Blum, S. A. “Single-Polymer−Particle Growth Kinetics with Molecular Catalyst Speciation and Single-Turnover Imaging” ACS Catal. 2019, 9, 3375−3383 Link

image001.png

45. Tu, K. N., Kim, S., Blum, S. A. “Copper-Catalyzed Aminoboration from Hydrazones To Generate Borylated Pyrazoles.” Org. Lett. 201921, 1283. Link

2018

image002 (2).jpg

44. Bel Abed, H.; Blum, S. A. “Transition Metal-Free Synthesis of Borylated Thiophenes via Formal Thioboration.” Org. Lett. 201820, 6673. Link

image003.jpg

43. Tu, K. N.; Gao, C.; Blum, S. A. “An Oxyboration Route to a Single Regioisomer of Borylated Dihydrofurans and Isochromenes.” J. Org. Chem. 201883, 11204. Link

image004 (2).jpg

42. Easter, Q. T.; Blum, S. A. “Kinetics of the Same Reaction over Nine Orders of Magnitude in Concentration: When Are Unique Subensemble and Single-Turnover Reactivity Displayed?” Angew. Chem. Int. Ed. 2018, 57, 12027. Link

image005 (2).jpg

41. Easter, Q. T.; Blum, S. A. “Evidence for Dynamic Chemical Kinetics at Individual Molecular Ruthenium Catalysts.” Angew. Chem. Int. Ed. 201857, 1572. Link

2017

image005.gif

40. Issaian, A.; Tu, K. N.; Blum, S. A. “Boron Heteroatom Addition Reactions via Borylative Heterocyclization: Oxyboration, Aminoboration, and Thioboration.” Acc. Chem. Res. 201750, 2598. Link

image006 (2).jpg

39. Easter, Q. T.; Blum, S. A. “Single Turnover at Molecular Polymerization Catalysts Reveals Spatiotemporally Resolved Reactions.” Angew. Chem. Int. Ed. 201756, 13772. Link

Highlighted in Angew. Chem. Int. Ed. “Kinetics in the Real World.” Link

Highlighted in UCI News Brief, “Little green flashes unlock secrets of catalytic reactions”. Link

image008.gif

38. Issaian, A.; Faizi, D. J.; Bailey, J. O.; Mayer, P.; Berionni, G.; Singleton, D. A.; Blum, S. A. “Mechanistic Studies of Formal Thioboration Reactions of Alkynes.” J. Org. Chem. 201782, 8165. Link

image009.gif

37. Kazuhiro, K.; Blum, S. A. "Structure–Reactivity Studies of Intermediates for Mechanistic Information by Subensemble Fluorescence Microscopy." ACS Catal20177, 3786. Link

image010.gif
image010 (2).jpg

36. Feng, C.; Easter, Q. T.; Blum, S. A. "Structure–Reactivity Studies, Characterization, and Transformation of Intermediates by Lithium Chloride in the Direct Insertion of Alkyl and Aryl Iodides to Metallic Zinc Powder." Organometallics 201736, 2389. Link
Organometallics, Cover, July 2017:

image011.gif

35. Faizi, D. J.; Davis, A. J.; Meany, F. B.; Blum, S. A. "Catalyst-Free Formal Thioboration to Synthesize Borylated Benzothiophenes and Dihydrothiophenes." Angew. Chem. Int. Ed. 201655, 14286. Link

Highlighted in Synfacts 201713, 71. "Ring-forming Thioboration of C–C π-Bonds." Link

2016

image013.gif

34. Feng, C.; Cunningham, D. W.; Easter, Q. T.; Blum, S. A. "Role of LiCl in Generating Soluble Organozinc Reagents." J. Am. Chem. Soc2016138, 11156. Link

Highlighted in Org. Process Res. Dev. 201620, 1691. "Some Items of Interest to Process R&D Chemists and Engineers." Link

image014.gif

33. Faizi, D. J.; Nava, N. A.; Al-Amin, M.; Blum, S. A. "Oxyboration: Synthesis of Borylated Benzofurans." Org. Synth. 201693, 228. Link

image014 (2).jpg

32. Johnson, J. S.; Chong, E.; Tu, K. N.; Blum, S. A. "Kinetic Study of Carbophilic Lewis Acid Catalyzed Oxyboration and the Noninnocent Role of Sodium Chloride" Organometallics 201635, 655. Link

image015.png

31. Faizi, D. J.; Issaian, A.; Davis, A. J.; Blum, S. A. "Catalyst-Free Synthesis of Borylated Lactones from Esters via Electrophilic Oxyboration" J. Am. Chem. Soc. 2016138, 2126. Link

30. Hirner, J. J.; Faizi, D. J.; Blum. S. A. Organoboron Compounds and Methods of Making Organoboron Compounds. U. S. Patent 9,238661, January 19, 2016.

image016.jpg

29. Tu, K. N.; Hirner, J. J.; Blum, S. A. "Oxyboration with and without a Catalyst: Borylated Isoxazoles via B–O σ-Bond Addition." Org. Lett. 201618, 480. Link

Highlighted in Synfacts 201612, 400. Link

2015

28. Chong, E.; Blum, S. A. "Aminoboration: Addition of B–N σ Bonds Across C–C π Bonds." J. Am. Chem. Soc. 2015137, 10144. Link

image018.png

27. Hirner, J. J.; Blum, S. A. "NMR Spectroscopy Studies of Electronic Effects and Equilibrium in the Organogold-to-boron Transmetallation Reaction and Studies Towards Its Application to the Alkoxyboration Addition of Boron-Oxygen Sigma-Bonds to Alkynes." Tetrahedron 201571, 4445. Special invited issue in honor of Yoshi Nakao's Tetrahedron Young Investigator AwardLink

image018.gif

26. Easter, Q. T.; Trauschke, V.; Blum, S. A." Catalyst Inefficiencies: Supported Ring-Opening Metathesis Polymerization Catalyst Yields Its Ensemble Rate from a Small Number of Molecular Active Sites." ACS Catal. 20155, 2290. Link

2014

image020.gif

25. Al-Amin, M.; Johnson, J. S.; Blum, S. A. "Selectivity, Compatibility, Downstream Functionalization, and Silver Effect in the Gold and Palladium Dual-Catalytic Synthesis of Lactones." Organometallics 201433, 5448. Link

image020.jpg
image021.png

24. Hensle, E. M.; Esfandiari, N. M.; Lim, S. -G.; Blum, S. A. "BODIPY Fluorophore Toolkit for Probing Chemical Reactivity and for Tagging Reactive Functional Groups." Eur. J. Org. Chem. 2014, 3347. Link
EurJOC, Cover, June 2014 Link

image023.jpg

23. Blum, S. A. "Location Change Method for Imaging Chemical Reactivity and Catalysis with Single-Molecule and -Particle Fluorescence Microscopy." Phys. Chem. Chem. Phys. 201416, 16333. Link

PCCP, Cover, August 2014 Link

image024.png

22. Hirner, J. J.; Faizi, D. J.; Blum, S. A. "Alkoxyboration: Ring-Closing Addition of B–O Sigma Bonds Across Alkynes." J. Am. Chem. Soc. 2014136, 4740. Link

Highlighted in Science 2014344, 10. "A Big Break for Boron." Link

Organoboron building blocks for drug discovery from this paper are available from Sigma-Aldrich. Link

image024.jpg

21. Al-Amin, M.; Roth, K. E.; Blum, S. A. "Mechanistic Studies of Gold and Palladium Cooperative Dual-Catalytic Cross-Coupling Systems." ACS Catal. 20144, 622. Link

2013

image026.jpg

20. Cordes, T.; Blum, S. A. "Opportunities and challenges in single-molecule and single-particle fluorescence microscopy for mechanistic studies of chemical reactions." Nat. Chem. 20135, 993. Link

image027.jpg

19. Fast, A.; Esfandiari, N. M.; Blum, S. A. "Small Number of Active Sites and Single-Locus Kinetics Revealed in (salph)Co-Catalyzed Ethylene Oxide Polymerization." ACS Catal. 20133, 2150. Link

image028.jpg

18. Hensle, E. M; Blum, S. A. "Phase Separation Polymerization of Dicyclopentadiene Characterized by In Operando Fluorescence Microscopy." J. Am. Chem. Soc. 2013135, 12324. Link

2012

image028.gif

17. Hirner, J. J.; Roth, K. E.; Shi, Y.; Blum, S. A. "Mechanistic Studies of Azaphilic versus Carbophilic Activation by Gold(I) in the Gold/Palladium Dual-Catalyzed Rearrangement of Alkenyl Vinyl Aziridines." Organometallics 201231, 6843. Link

16. Gladysz, J. A.; Ball, Z. T.; Bertrand, G.; Blum, S. A.; Dong, V. M.; Dorta, R.; Hahn, F. E.; Humphrey, M. G.; Jones, W. D.; Klosin, J.; Manners, I.; Marks, T. J.; Mayer, J. M.; Rieger, B.; Ritter, J.; Sattelberger, A. P.; Schomaker, J. "Organometallics Roundtable 2011." Organometallics 201231, 1. Link

image030.gif

15. Cornell, T. P.; Shi, Y.; Blum, S. A. "Synthesis of Alkenylgold(I) Compounds via Sequential Hydrozirconation and Zirconium to Gold Transmetalation." Organometallics 2012, 31, 5990. Link

2011

image031.gif

14. Esfandiari, N. M.; Blum, S. A. "Homogeneous vs Heterogeneous Polymerization Catalysis Revealed by Single-Particle Fluorescence Microscopy." J. Am. Chem. Soc. 2011133, 18145. Link
Highlighted Editor's Choice, Science 2011334, 1034. "A Probe of Homogeneity." Link

image032.gif

13. Esfandiari, N. M.; Wang, Y.; Bass, J. Y.; Blum, S. A. "Deconvoluting Subensemble Chemical Reaction Kinetics of Platinum–Sulfur Ligand Exchange Detected with Single-Molecule Fluorescence Microscopy." Inorg. Chem. 201150, 9201. Link

image033.gif

12. Roth, K. E.; Blum, S. A. "Direct Observation of Gold/Palladium Transmetalation in an Organogold Heck Reaction." Organometallics 201130, 4811. Link

image034.gif

11. Hirner, J. J.; Shi, Y.; Blum, S. A. "Organogold Reactivity with Palladium, Nickel, and Rhodium: Transmetalation, Cross-Coupling, and Dual Catalysis." Acc. Chem. Res. 201144, 603. Link

One of the "Most Read" Accounts articles

image035.gif

10. Shi, Y.; Blum, S. A. "Gold and Rhodium Transmetalation: Mechanistic Insights and Dual-Metal Reactivity." Organometallics 201130, 1776. Link

image035.jpg

9. Hirner, J. J.; Blum, S. A. "Nickel-Catalyzed Cross-Coupling of Organogold Reagents." Organometallics 2011, 30, 1299. Link

2010

image037.jpg
image038.jpg

8. Esfandiari, N. M.; Wang, Y.; Mcintire, T. M.; Blum, S. A. "Real-Time Imaging of Platinum-Sulfur Ligand Exchange Reactions at the Single-Molecule Level via a General Chemical Technique." Organometallics 201030, 2901. Link
Organometallics Cover, June 2011:

image039.jpg
image040.jpg

7. Esfandiari, N. M.; Wang, Y.; Bass, J. Y.; Cornell, T. P.; Otte, D. A. L.; Cheng, M. H.; Hemminger, J. C.; Mcintire, T. M.; Mandelshtam, V. A.; Blum, S. A. "Single-Molecule Imaging of Platinum Ligand Exchange Reaction Reveals Reactivity Distribution." J. Am. Chem. Soc. 2010132, 15167. Link
Highlighted in Chem. & Eng. News 201088 (36), 14. 
ournal of the American Chemical Society Cover, November 2010:

image041.gif

6. Roth, K. E.; Blum, S. A. "Relative Kinetic Basicities of Organogold Compounds." Organometallics 2010, 29, 1712. Link

2009

image042.gif

5. Shi, Y.; Roth, K. E.; Ramgren, S. D.; Blum, S. A. "Catalyzed Catalysis Using Carbophilic Lewis Acidic Gold and Lewis Basic Palladium: Synthesis of Substituted Butenolides and Isocoumarins." J. Am. Chem. Soc. 2009131, 18022. Link

image043.gif

4. Lim, S.-G.; Blum, S. A. "A General Fluorescence Resonance Energy Transfer (FRET) Method for Observation and Quantification of Organometallic Complexes under Reaction Conditions." Organometallics 200928, 4643. Link

image044.gif

3. Shi, Y.; Ramgren, S. D.; Blum, S. A. "Palladium-Catalyzed Carboauration of Alkynes and Palladium/Gold Cross-Coupling." Organometallics 200928, 1275. Link
Highlighted in ACS-Petroleum Research Fund Feature Story, "A Synergy of Synthetic Chemistry"

2008

image044.jpg

2. Canham, S. M.; Bass, J. Y.; Navarro, O.; Lim, S. G.; Das, N.; Blum, S. A. "Toward the Single-Molecule Investigation of Organometallic Reaction Mechanisms: Single-Molecule Imaging of Fluorophore-Tagged Palladium(II) Complexes." Organometallics 200827, 2172. Link
Highlighted in Chem. & Eng. News 200886, 43.

image046.jpg

1. Shi, Y.; Peterson, S. M.; Haberaecker, W. W., III; Blum, S. A. "Alkynes as Stille Reaction Pseudohalides: Synthesis of Tri- and Tetra-Substituted Olefins." J. Am. Chem. Soc. 2008130, 2168. Link
Highlighted in Angew. Chem. Int. Ed. 200847, 5703. Link